This week I’m reviewing work underway at the Health Prevention Trials Network (HPTN) on PrEP, or pre-exposure prophylaxis of HIV. This is giving HIV medication to people who are negative who are at high risk of becoming infected.
If you are wondering why it’s not just for whores, watch this video:
So Truvada is for anybody who might have an occasional slip up or regular slip ups in terms of using a condom during sex. One of the concerns about PrEP is that it could be challenging to take daily, as currently recommended. Would it work if you took it less frequently? That is a question waiting for an answer.
The HPTN 067 or ADAPT Study is going to help answer that question. ADAPT stands for “Alternative Dosing to Augment PrEP pill-Taking”. Clever name, don’t you think?
This study will examine what is the most effective way to take PrEP. One third of the participants will take Truvada daily, 1/3 will take it just before and after sex, and the final 1/3 will take it two times a week and a booster after sex.
Participants should take no more than 2 tablets in a 24-hour period or seven tablets in a week.
This study will enroll men who have sex with men (MSM) and women.
If intermittent PrEP works as well or better than daily PrEP, this would make PrEP more acceptable, easier to use, possibly safer, and less expensive.
The ADAPT study is taking place in Cape Town, South Africa, Bangkok, Thailand, and New York, US.
What about other medications besides Truvada for PrEP? Tomorrow we’ll look at a study that is looking at maraviroc for PrEP.
Are you taking PrEP? Are you enrolled in a trial, getting it through your doctor’s office, or somewhere else?